Compared to the other center epidemiology has an integrative function. Main tasks are the choice of study design and planning of projects as well as analysis of data. This includes the ascertainment of study subjects and their data with questionnaires, the development of data entry and storage procedures and the data management. A special focus in occupational medicine is set on the quantification of exposures, for example with job-exposure matrixes and the use of appropriate exposure metrics for risk estimation. Complex statistical models are used to adjust for confounders The epidemiological methods applied in the research projects support quality assurance in the conduct of the studies. In order for threshold limit values to be defined, agent-specific effects of occupational risk factors must be evaluated on the basis of statistical models.