The Molecular Medicine center of competence is divided into the following divisions:
Research at the Molecular Medicine center of competence focuses on the mechanisms of carcinogenesis and early diagnosis of work-related cancer. This also includes the investigation of synergistic interactions of different carcinogens in settings of mixed exposure. A number of tools have been established and are continuously refined to detect changes in the genome and epigenome that are connected to the impact of hazardous substances and the development of cancer.
Cutting-edge analysis methods are employed in order to identify specific patterns in gene expression and new biomarkers for early detection. Together with the Medicine, Allergy/Immunology and Epidemiology centers of competence, interdisciplinary approaches are pursued to validate promising new molecular markers for early detection of cancer in prospective cohort studies. A further research focus is that into the relationship between sequence variations in the genes of enzymes, which metabolize foreign substances, and susceptibility to occupational hazardous substances.
Georg Johnen, Dr. rer. nat.
Phone: +49 (0)234 302-4509