The Competence Centre Molecular Medicine is divided into the following sections:
The Competence Centre Molecular Medicine uses modern molecular biological methods and biobanking to address a wide range of issues facing the accident insurance institutions and occupational medicine in general. An important objective is the development of new methods for the early detection, diagnosis, and ultimately also treatment of occupational diseases. In this context, the (secondary) prevention of occupational cancer, which has a tremendous impact upon affected insured individuals, is a particular focus of the research activity. Effective and minimally invasive early detection is a valuable addition to the traditional methods of follow-up examinations.
The competence centre conducts research into specific effects of hazardous substances upon the genes and their regulation, and thus the mechanisms of tumour development. Cutting-edge analysis methods are employed in order to identify specific patterns in gene expression and new biomarkers for early detection. The priority lies upon validation of these biomarkers in large-scale prospective studies. This includes the establishment of a large biobank of prediagnostic samples. A further research focus is that into the relationship between sequence variations in the genes of enzymes which metabolize foreign substances, and susceptibility to occupational hazardous substances.
Georg Johnen, Dr. rer. nat.
Tel. +49 30 13001-4350